Propain Syrup Quá liều

Symptoms: Symptoms of overdosage include headache, heartburn, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhea, disorientation, excitation, drowsiness, dizziness, tinnitus, fainting. In cases of significant poisoning acute renal failure and liver damage are possible. In adults, overdoses from 5 to 25 g have been described without any specific adverse effects, yet in some individuals overdoses as low as 6-12 g have caused a serious intoxication (metabolic acidosis, renal failure, convulsions, apnoea, central nervous system suppression).
Respiratory depression and coma may occur after the ingestion of NSAIDs but are rare.
In one case of naproxen overdose, transient prolongation of the prothrombin time due to hypothrombinaemia may have been due to selective inhibition of the synthesis of vitamin-K dependent clotting factors.
A few patients have experienced seizures, but it is not known whether these were naproxen-related or not. It is not known what dose of the drug would be life-threatening.
Management: Patients should be treated symptomatically as required. Activated charcoal should be administered to the patient within one hour to inhibit absorption and to interrupt the enterohepatic circulation. Alternatively in adults gastric lavage should be considered within one hour of ingestion of a potentially life-threatening overdose.
Hemodialysis does not decrease the plasma concentration of naproxen because of the high degree of protein binding. However, hemodialysis may still be appropriate in a patient with renal failure who has taken naproxen. Hemodialysis can accelerate the elimination of the main metabolite of naproxen, 6-O-demethylnaproxen.
Administration of an H2 blocker or proton pump inhibitor should be considered to prevent gastrointestinal complications. Good urine output should be ensured. Renal and liver function should be closely monitored.
Patients should be observed for at least four hours after ingestion of potentially toxic amounts. Frequent or prolonged convulsions should be treated with intravenous diazepam.
Other measures may be indicated by the patient's clinical condition.