Propain Syrup Liều dùng/Hướng dẫn sử dụng

Method of administration: For oral administration: To be taken preferably with or after food.
Adverse drug reactions can be reduced by taking the lowest effective dose for the shortest duration possible to manage the symptoms.
Posology: Adults: Usually, 250-500 mg (10-20 mL) twice a day based on the individual need.
If the predominant symptom in rheumatoid arthritis is morning stiffness, a single dose of 500-750 mg (20-30 mL) in the evenings may be adequate.
In the treatment of acute gout, the recommended dose is 750 mg at once then 250 mg every 8 hours until the attack has passed.
In the treatment of acute musculoskeletal disorders and dysmenorrhoea, the recommended dose is 500 mg initially followed by 250 mg at 6-8 hour intervals as needed, with a maximum daily dose after the first day of 1250 mg.
Pediatric population (over 5 years): For juvenile rheumatoid arthritis: in children aged over 5 years, the recommended daily dose is 10 mg/kg divided into two doses. Dosing as per the table as follows. Patients weighing over 50 kg may be administered the adult dosage. (See Table 1.)


Click on icon to see table/diagram/image


Elderly patients: Compared with younger patients, the plasma concentration of unbound naproxen is higher, and the elimination of naproxen is slower in those aged over 70 years. Elderly patients are more susceptible to adverse effects of antiinflammatory analgesics than other patients. Due to these reasons, lower single doses, i.e. 250 mg (10 mL) twice a day, are recommended for elderly patients. The patient should be monitored regularly for GI bleeding during NSAID therapy.
Renal failure: For patients with mild renal failure, the lowest effective dose should be used, and renal function must be monitored. If possible, the use of naproxen should be avoided in patients with moderate renal failure (creatinine clearance 50-10 mL/min or S-CR 160-565 micromol/L). Naproxen is contraindicated in patients with severe renal impairment.
Hepatic failure: Naproxen should be used with caution in patients with mild to moderate hepatic failure or cirrhotic hepatic diseases. The lowest effective dose should be administered. Naproxen is contraindicated in patients with severe hepatic impairment.