Contraindicated for use in the following cases: Third trimester of pregnancy; A history of asthma, rhinitis, nasal polyps or urticarial in association with acetylsalicylic acid or NSAIDs; Hypersensitivity to the active substance or to any of the excipients of this medicine; Severe cardiac failure; Severe renal and hepatic impairment; History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy; Active gastric or duodenal ulcer, or history of recurrent peptic ulcer/hemorrhage (two or more distinct episodes of proven ulceration or bleeding); Other conditions predisposing to gastrointestinal hemorrhages.
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