Concise Prescribing Info
Contents
Acemetacin
Indications/Uses
RA, OA, ankylosing spondylitis, gout.
Dosage/Direction for Use
Adult 1 cap daily. Acute cases, acute gout 1 cap bid. Max treatment duration: 5 days.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to acemetacin or indomethacin. Blood coagulation disorder; GI ulcers. Pregnancy & lactation. Childn <16 yr.
Special Precautions
Allergy to NSAIDs. Not to be used in patients w/ history of peptic or duodenal ulcers; blood abnormalities. Patients w/ high BP, heart disease (heart function disorder), or just undergone major surgery. History of asthma, skin rashes or any allergic reactions, chronic obstructive airway disease, hay fever & nasal polyps. May aggravate psychiatric disorders, epilepsy, & parkinsonism. Periodically screen renal & hepatic function & blood counts in patients receiving long-term treatment. Monitor blood K or lithium salt content when used simultaneously w/ diuretics. Concomitant use w/ anticoagulants & blood sugar lowering drugs. May increase dizziness w/ alcohol intake. Do not drive or operate dangerous machinery in case of vertigo. Liver or kidney disease. Elderly.
Adverse Reactions
Nausea, vomiting, abdominal pain & cramps, diarrhea, GI perforation, hemorrhage, discomfort & bleeding, indigestion, bloating, loss of appetite, peptic ulcer; headache, agitation, anxiety, fatigue, confusion, depression, tinnitus, dizziness, loss of consciousness, complete comatose, myasthenia, profuse perspiration, nervous breakdown, paranoia, borderline neurosis, cerebral palsy, shortage of memory, unusual taste sensory & abnormal vision (blurred & double vision, sees black spot & halo), hearing impairment, memory loss, convulsions, insomnia, nightmare, trembling; retinal pigmentation, corneal erosion & blurred vision w/long-term use; lesion on liver, pancreatitis, increased blood sugar, diabetes; kidney damage, albuminuria, blood in urine; high BP, heart circulatory system discomfort, palpitation; skin rash, itchiness, urticaria, mouth sores, alopecia, eczema, dermatitis, skin bleeding & swelling, SJS, Lyell syndrome, drooping eyelids, swelling of tongue, throat inflammation, breathing difficulty, palpitation, low BP, shock, anaphylaxis, pneumonia; anaemia, high leucocyte count, low platelet count; blood in urine, increased blood K, kidney dysfunction & edema in hypertensive patient, nephrotoxicity.
Drug Interactions
May affect acemetacin blood conc w/ cardiac stimulants, phenytoin & lithium. May decrease efficacy of antihypertensives eg, ACE inhibitor. Increased elimination process of furosemide. May cause renal dysfunction w/ ACE inhibitors. May increase blood K level w/ diuretics. GI side effects w/ other NSAIDs. Contraindicated w/ MTX. Inhibited excretion w/ gout medicine, probenecid or sulfinpyrazone. Increased risk of haemorrhage w/ blood coagulants. Increased kidney toxicity w/ cyclosporine. Decreased blood conc w/ aspirin. Concomitant use w/ central neural agents & alcohol. May cause acute renal dysfunction w/ triamterene. Increased conc & cause fatal stomach hemorrhaging w/ diflunisal. Delayed penicillin elimination.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC Classification
M01AB11 - acemetacin ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.
Presentation/Packing
Form
Aceo cap 90 mg
Packing/Price
500's
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