Đăng xuất
Pharmacotherapeutic group: Nonsteroidal anti-inflammatory drug. ATC code: M01AB08.
Pharmacology: Pharmacodynamics: Anti-inflammatory activity, analgesic activity, antipyretic activity.
Inhibitory activity on the synthesis of prostaglandins.
Inhibitory activity on platelet aggregation.
Pharmacokinetics: Absorption: Etodolac is rapidly absorbed orally: The serum peak is reached approximately 1 hour after administration. Bioavailability is high (close to 100 percent). Taking etodolac with meals does not affect the amount of drug absorbed but does delay the onset of peak plasma levels.
Distribution: Etodolac is extensively bound to plasma proteins (greater than or equal to 99 percent). The volume of distribution is 0.4 1/kg. The elimination half-life is approximately 7 hours. In plasma, etodolac is found primarily in the unconjugated and glucuronide form.
Elimination: Etodolac is eliminated mainly via the urine (75 percent) in the hydroxylated and glucuronide form and via the faeces (25 percent).
The pharmacokinetic parameters of bioavailability and the elimination half-life are identical in young subjects and subjects over 65 years of age.
Renal impairment appears to have little effect on the pharmacokinetics of etodolac.
