Đăng xuất
Doses of 400 mg/kg in children may cause symptoms. In adults, dose-response effects are less pronounced. The half-life of overdose is 1.5-3 hours.
Symptom: The symptoms of overdose usually are: nausea, stomach pain, vomiting (bleeding) and diarrhea (bloody), dizziness, cramps, nystagmus and double vision, headache and tinnitus.
In more severe cases of poisoning, toxicity is seen in the central nervous system, manifested by drowsiness, occasional irritation and disorientation or coma. Sometimes patients have seizures.
In severe cases of poisoning, metabolic acidosis may occur with impaired renal function, hypotension, impaired consciousness, and coma (it is unclear whether impaired renal function is a consequence of intoxication or hypotension). Due to the influence of coagulation factors, prothrombin/INR clotting time may be prolonged. Acute renal failure and liver damage may occur. Paroxysmal asthma attacks can occur in asthmatic patients.
Prolonged use at doses higher than recommended can lead to severe hypokalemia and tubular acidosis. Symptoms may include decreased levels of consciousness and general weakness.
Treatment: Ibuprofen overdose should be treated immediately. There is no specific antidote for ibuprofen. The stomach should be emptied as soon as possible. The patient should be encouraged to vomit if possible. Activated charcoal may be used to reduce the absorption of ibuprofen. Consider charcoal within 1 hour of ingestion of a potentially toxic amount. Gastric lavage and supportive treatment of severe electrolyte disturbances are recommended. If seizures are frequent or prolonged, treatment should include intravenous diazepam or lorazepam. Bronchodilators should be used for asthma.
