Ibuprofen is contraindicated in the following cases: Hypersensitivity to ibuprofen or any ingredient of the drug; Women in the last 3 months of pregnancy (see Use in Pregnancy & Lactation); Patients with a history of hypersensitivity reactions (e.g. bronchospasm, asthma, rhinitis, angioedema, urticaria with other NSAIDs, aspirin); Patients with a history of gastrointestinal bleeding or perforation during previous treatment with NSAIDs; Patients with gastrointestinal haemorrhage, cerebrovascular haemorrhage or other progressive haemorrhage, such as ulcerative colitis; Patients with active peptic ulcer, history of peptic ulcer or recurrent bleeding (2 or more separate bleeding episodes or ulcers); Severe hepatic impairment; Severe kidney failure; Internal hemorrhage; Severe heart failure (NYHA Class IV); Systemic Lupus Erythematosus; Combined with mifamurtide (see Interactions).
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