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Pharmacotherapeutic Group: Anti-inflammatory and antirheumatic, non-steroidal. ATC Code: M01AB16.
Pharmacology: Pharmacodynamics: Aceclofenac is a derivative of phenylacetic acid, with anti-inflammatory and analgesic effects. It works by inhibiting cyclooxygenase (COX), an enzyme that plays a crucial role in the formation of prostaglandins (chemical mediators involved in inflammation and pain reactions).
Pharmacokinetics: After oral administration, aceclofenac is rapidly absorbed. Peak plasma concentration is reached within 1.25 to 3 hours.
Aceclofenac is highly bound to plasma proteins (over 99%). It distributes into synovial fluid at a concentration of approximately 57% compared to plasma concentration. The volume of distribution is approximately 25 L.
The average half-life is about 4 hours. Aceclofenac in plasma is mainly in its unchanged form. The primary metabolite found in plasma is 4'-Hydroxyaceclofenac. About 2/3 of the dose is excreted through the kidneys, primarily in its hydroxylated form.
The pharmacokinetic properties of aceclofenac remain unchanged in elderly individuals.
