Gastrointestinal: Gastric ulcers, perforation, or gastrointestinal bleeding, sometimes fatal, especially in the elderly, may occur. Nausea, vomiting, diarrhea, bloating, constipation, indigestion, abdominal pain, black stools, hemorrhage, and ulcerative stomatitis exacerbation of colitis ulcerative and Crohn's disease have been reported after taking the drug. Less frequently, gastritis has been observed. Pancreatitis has been reported very rarely.
Hypersensitivity Reactions: Hypersensitivity reactions have been reported following treatment with NSAIDs. These may include non-specific allergic reactions and respiratory anaphylaxis, including asthma, severe asthma, bronchospasm, or difficulty breathing, as well as various skin disorders, including rashes, itching, urticaria, angioedema, and, rarely, epidermal necrolysis and polycythemia.
Other less common adverse reactions reported include: Renal: Interstitial nephritis.
Neurological and Special Senses: Optic neuritis, reports of aseptic meningitis (especially in patients with pre-existing autoimmune disorders, such as systemic lupus erythematosus or mixed connective tissue disease), with symptoms such as neck stiffness, headache, nausea, vomiting, fever, disorientation, confusion, hallucinations, discomfort, and drowsiness.
Hematologic: Agranulocytosis, aplastic anemia.
Dermatology: Severe reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis (very rare). Hypersensitivity.
If adverse effects occur, aceclofenac should be discontinued.
Common: Loss of appetite, abdominal pain, nausea, diarrhea; dizziness; elevated liver enzymes.
Uncommon: Bloating, gastritis, constipation, vomiting, gastric ulcer; fatigue; itching, rash, eczema, dermatitis, urticaria; increased BUN, increased blood creatinine.
Rare: Anemia, hypersensitivity reactions, visual disturbances, shortness of breath, black stools, angioedema.
Report any side effects to a doctor.
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