Lithium, digoxin: Increases the plasma concentrations of lithium and digoxin.
Anticoagulants: Enhances the anticoagulant effect.
Methotrexate: Increases plasma concentrations of methotrexate, leading to increased toxicity when combined with NSAIDs within 24 hours after taking methotrexate.
Cyclosporine: Increases the nephrotoxicity of cyclosporine.
Antihypertensive drugs: Reduces the antihypertensive effect.
Diuretics: Reduces the diuretic effect and increases NSAID nephrotoxicity.
Monitor potassium levels when using potassium-sparing diuretics or ACE inhibitors.
Corticosteroids, other NSAIDs, antiplatelet drugs, and selective serotonin reuptake inhibitors (SSRIs): Increases the risk of gastrointestinal ulcers and bleeding.
Quinolones: Increase the risk of seizures.
Mifepristone: NSAIDs should not be used after mifepristone within 8-12 days as they may reduce the effectiveness of mifepristone.
Tacrolimus: Increases the risk of nephrotoxicity.
Zidovudine: Increases the risk of hematological toxicity.
Ritonavir: Increases the plasma concentration of aceclofenac.