Đăng xuất
To minimize the risk of adverse events, LEFGEN should be used at the lowest effective daily dose for the shortest duration possible (see Precautions).
It should be taken with food or immediately after a meal.
Adults: The recommended dose is 100 mg twice daily.
Children: There is no clinical data regarding the use of Aceclofenac in children, and therefore it should not be used in children under 18 years old.
Elderly: Elderly individuals are more likely to have impaired renal, cardiovascular, or hepatic function and may be using other medications concurrently, which increases the risk of serious adverse effects. If NSAID therapy is required, the lowest effective dose for the shortest duration should be used. Patients should be regularly monitored for gastrointestinal bleeding during NSAID treatment.
Aceclofenac's pharmacokinetics are not altered in elderly patients, so no dosage adjustments or changes in treatment duration are required.
Renal impairment: There is no evidence to suggest that dose adjustment is necessary for patients with mild renal impairment. However, like other NSAIDs, caution is advised.
Hepatic impairment: There is some evidence suggesting that the dose of Aceclofenac should be reduced in patients with liver impairment, with the starting dose reduced to 100 mg/day.
