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Pregnancy: Clinical data from the use of polymyxin B sulphate in pregnant women is not available. Polymyxin B for injection should not be used during pregnancy unless the expected benefit to the mother outweighs any possible risk to the fetus.
Animal studies are also lacking with respect to embryotoxicity and/or teratogenicity of polymyxin B sulphate.
Breast-feeding: It is not known whether polymyxin B sulphate is secreted in breast or animal milk. Because of the potential for unknown effects of the drug in infants being nursed by mothers taking polymyxin B sulphate, a decision should be made to either discontinue nursing or discontinue treatment, taking into account the importance of polymyxin B for injection drug treatment to the mother and the possible risk to the infant.
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