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Intravenous (IV): Loading dose: 20,000 to 25,000 units/kg (2.0 to 2.5 mg/kg), based on total body weight (TBW), infused over 1 hour.
Maintenance dose: 12,500 to 15,000 units/kg (1.25 to 1.5 mg/kg), based on TBW every 12 hours is infused over 1 hour.
Patients with Renal Impairment: Polymyxin B is not significantly eliminated by kidneys and therefore the daily maintenance dose of polymyxin B should not be adjusted.
Patients receiving Renal Replacement Therapy: The loading dose and maintenance dose of polymyxin B should not be adjusted.
Method of administration: Dissolve 500,000 units (50 mg) polymyxin B for injection in 50 to 500 mL of dextrose Injection 5 percent, for continuous IV infusion.
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