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Polymyxin-induced toxicity associated with overdose has been reported. Overdose of polymyxin can result in neuromuscular blockade, which can lead to apnea, muscular weakness, vertigo, transient facial paresthesia, slurred speech, vasomotor instability, visual disturbance, confusion, psychosis and possible respiratory arrest. Overdose can also cause renal failure characterized by decreased urine output and increased serum concentrations of BUN and creatinine.
There is no specific antidote for polymyxin B sulphate overdose. In case of polymyxin B sulphate overdose, the drug should be stopped and symptomatic treatment instituted.
Quick diuresis by IV administered mannitol may help to enhance renal clearance of the drug and thus to reduce serum drug level. Hemodialysis or peritoneal dialysis may help in order to manage renal complications.
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