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Overview: Concomitant administration of diuretics and potential nephrotoxic and/or neurotoxic agents including antimicrobials increases the likelihood of renal toxicity, whereas non-polarizing muscle relaxants and other neurotoxic drugs increase the likelihood of serious neurotoxicity.
Drug-Drug Interactions: The concurrent use of other nephrotoxic and/or neurotoxic drugs particularly bacitracin, kanamycin, streptomycin, tobramycin, amikacin, cephaloridine, cephalothin, paromomycin, polymyxin E (colistin), neomycin, gentamicin, and vancomycin should be avoided (see Neurologic under Precautions).
Due to the effect of polymyxin B sulphate on the release of acetylcholine, non-polarizing muscle relaxants (ether, tubocurarine, gallamine, decamethonium, sodium citrate), depolarizing muscle relaxant succinylcholine, and other neurotoxic drugs should not be used concurrently with polymyxin B sulphate (see Respiratory under Precautions).
The concurrent use of polymyxin B for injection with potent diuretics such as ethacrynic acid or furosemide should be avoided, since diuretics may enhance polymyxin B sulphate toxicity by altering the antibiotic concentration in serum and tissues.
Drug-Food Interactions: Information not available.
Drug-Herb Interactions: Information not available.
Drug-Laboratory Interactions: Information not available.
Drug-Lifestyle Interactions: Information not available.
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