Poliz-B Indications/Uses

Polymyxin B for injection (polymyxin B sulphate) is used as monotherapy or combination with relevant antibiotics for the treatment of extensively drug-resistant gram negative bacterial infections with limited treatment options, mainly the susceptible strains of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia.
Polymyxin B for Injection is indicated for the treatment of patients with the following infections, when caused by susceptible strains of the designated aerobic gram negative bacteria: Urinary tract infections caused by Pseudomonas aeruginosa and Escherichia coli.
Bloodstream infections caused by Pseudomonas aeruginosa, Enterobacter (formerly called Aerobacter) aerogenes and Klebsiella pneumonia.
Polymyxin B for injection should be used where sensitivity suggests more commonly used systemic antibacterial agents may be contraindicated or ineffective because of bacterial resistance.
Polymyxin B for injection should be used only in hospitalized patients under close monitoring for kidney function and neurological signs and symptoms.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of polymyxin B sulphate and other antibacterial drugs, polymyxin B for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.