Poliz-B Caution For Usage

Incompatibilities: Polymyxin B is inactivated by strong acidic or alkaline solutions. The drug is chemically incompatible with many drugs including amphotericin B, ampicillin sodium, cloxacillin sodium, cefiderocol sulfate tosylate, cefazolin, chloramphenicol sodium succinate, chlorothiazide sodium, and heparin sodium. Polymyxin B in solution is also incompatible with the salts of calcium and magnesium.
Special precautions for disposal and other handling: Polymyxin B for injection must be reconstituted before use, using aseptic technique.
The reconstituted solution should be clear. Do not use if particles are present.
Reconstitution for Intravenous Administration: Dissolve 500,000 units (50 mg) polymyxin B for injection (1 vial) in 50 to 500 mL of dextrose injection 5 percent, for continuous IV drip. Reconstituted solution should be stored under refrigeration (2-8°C and the unused portion should be discarded after 72 hours or should be stored below 30°C and the unused portion should be discarded after 3 hours.
The reconstituted solutions of POLIZ-B (500,000 UNITS FOR INJECTION) should be used immediately. If not used immediately, the solutions are stable under storage conditions which are mentioned in Shelf life under Storage.
For single use only. Any unused medicinal product or waste material should be disposed of in accordance with local requirements.