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Method of administration: The drug is used by intramuscular or intravenous injection. The injection solution must be drawn under aseptic conditions.
The duration of use should be determined by the treating physician. When the drug is used as a supplement to total parenteral nutrition solutions, it is necessary to ensure that the correct dose of selenium is used, which is 100 mcg (equivalent to 1 ampoule) per day.
The drug can be mixed with common infusion solutions. For safety reasons, attention should be paid to the non-specific precipitation in all infusion solutions after mixing with the injectable drug selenium.
Posology: 100 mcg selenium daily, short term up to 300 mcg selenium/day (corresponding to 1 ampoule or up to 3 ampoules per injection).
Treatment should continue until the selenium status normalizes (selenium in plasma 80-120 µg/l, in whole blood 100-140 μg/l). Regular testing of the selenium level at appropriate intervals is recommended.
When treating extreme nutritional deficiencies such as systemic inflammatory response syndrome (SIRS)/sepsis can only be achieved by administering higher levels. Doses of selenium (up to 1000 mcg/day per injection, sometimes up to 2000 mcg/day, per injection) one normalization of the selenium status can be achieved (selenium in plasma 80-120 μg/l, in whole blood 100-140 μg/l). Close monitoring of selenium levels is recommended. If values are above normal, the dose should be reduced. The administration of higher doses should be limited to 14 days. The lower toxicity limit is 900 μg/l plasma or 1000 μg/l whole blood.
