Đăng xuất
The recommended starting dose of olmesartan medoxomil is 10 mg once daily. In patients whose blood pressure is not adequately controlled at this dose, the dose of olmesartan medoxomil may be increased to 20 mg once daily as the optimal dose.
If additional blood pressure reduction is required, olmesartan medoxomil dose may be increased.
A maximum of 40 mg daily or hydrochlorothiazide therapy may be added.
The antihypertensive effect is substantially present within 2-8 weeks of initiating therapy.
Elderly: No adjustment of dosage is generally required in elderly people. The maximum dose is 40 mg daily.
Renal impairment: The maximum dose in patients with mild to moderate renal impairment (creatinine clearance of 20-60 mL/min) is 20 mg once daily. The use in patients with severe renal impairment (creatinine clearance <20 mL/min) is not recommended.
Hepatic impairment: No adjustment of dosage recommendations is required for patients with mild hepatic impairment.
In patients with moderate hepatic impairment, an initial dose of 10 mg once daily is recommended and the maximum dose should not exceed 20 mg once daily. Close monitoring of blood pressure and renal function is advised. Use is not recommended in severe hepatic impairment.
Pediatric population: From 6 to less than 18 years of age.
The starting dose of olmesartan medoxomil in children from 6 to less than 18 years of age is 10 mg once daily. In children whose blood pressure is not adequately controlled at this dose, the dose of olmesartan medoxomil may be increased to 20 mg once daily. If additional blood pressure reduction is required, in children who weigh ≥ 35 kg, the olmesartan medoxomil dose may be increased to a maximum of 40 mg. In children who weigh < 35 kg, the daily dose should not exceed 20 mg.
Pediatric population: From 1 to 5 years old.
The safety and efficacy of olmesartan medoxomil in children aged 1 to 5 years old have not yet been established. Olmesartan medoxomil should not be used in children below 1 year of age because of safety concerns and lack of data in this age group.
Method of administration: It is recommended that Olimestra be taken at about the same time each day, with or without food, for example at breakfast time. The tablet should be swallowed with a sufficient amount of fluid (e.g. one glass of water). The tablet should not be chewed.
