Lorinose

Loratadine

Symptomatic relief of allergic rhinitis eg, sneezing, nasal discharge (rhinorrhea) & itching, as well as ocular itching & burning. Chronic urticaria & other allergic dermatologic disorders.

Adult & childn ≥12 yr 1 tab once daily. Adult & childn ≥6 yr w/ renal impairment (GFR <30 mL/min) or hepatic failure Initially 10 mg every other day.

May be taken with or without food.

Hypersensitivity.

Hepatic impairment or renal insufficiency. Use lowest effective dose in pregnant women. Monitor breastfed infant for irritability, jitteriness, or drowsiness during lactation. Elderly.

Adult: Drowsiness, fatigue, headache, sedated state; skin rash; gastritis, nausea, xerostomia; hypersensitivity reaction. Childn: Nervousness; abdominal pain; diarrhea; vomiting; hyperkinetic muscle activity. Alopecia, anaphylaxis, cough, dizziness, dry nose, hepatic insufficiency, increased appetite, palpitations, seizure, tachycardia.

Avoid concomitant use w/ nasal aclidinium; nasal azelastine; bromperidol; cimetropium; eluxadoline; glycopyrrolate (oral inhalation); topical glycopyrronium; ipratropium (oral inhalation); lasmiditan; levosulpiride; orphenadrine; oxatomide; oxomemazine; paraldehyde; pitolisant; KCl; K citrate; revefenecin; thalidomide; tiotropium; umeclidinium. May increase levels/effects of ethyl alcohol; amezinium; anticholinergic agents; nasal azelastine; blonanserin; brexanolone; buprenorphine; cimetropium; CNS depressants; eluxadoline; flunitrazepam; glucagon; glycopyrrolate (oral inhalation); hydrocodone; methotrimeprazine; metyrosine; mirabegron; opioid agonists; orphenadrine; oxycodone; paraldehyde; piribedil; KCl; K citrate; pramipexole; ramosetron; revefenacin; ropinirole; rotigotine; SSRIs; suvorexant; thalidomide; thiazide & thiazide-like diuretics; tiotropium; topiramate; zolpidem. Increased levels/effects by aclidinium; alizapride; amantadine; amiodarone; botulinum toxin-containing products; topical brimonidine; bromopride; bromperidol; cannabidiol; cannabis; chloral betaine; chlormethiazole; chlorphenesin carbamate; topical dimethindene; doxylamine; dronabinol; droperidol; erdafitinib; esketamine; topical glycopyrronium; hydroxyzine; ipratropium (oral inhalation); kava kava; lasmiditan; lemborexant; lofexidine; lumacaftor; Mg sulfate; methotrimeprazine; mianserin; systemic minocycline; nabilone; oxatomide; oxomemazine; perampanel; P-gp/ABCB1 inhibitors; pramlintide; ranolazine; rufinamide; Na oxybate; tapentadol; tetrahydrocannabinol & cannabidiol; trimeprazine; umeclidinium. May decrease levels/effects of acetylcholinesterase inhibitors; benzylpenicilloyl polylysine; betahistine; prokinetic GI agents; hyaluronidase; itopride; levosulpiride; nitroglycerin; pitolisant; secretin. Decreased levels/effects by acetylcholinesterase inhibitors; amphetamines; lumacaftor; P-gp/ABCB1 inducers.

Antihistamines & Antiallergics

R06AX13 - loratadine ; Belongs to the class of other antihistamines for systemic use.

NDD