LORINOSE should be used cautiously in patients with hepatic impairment or renal insufficiency, including geriatric patients, have decreased clearance of the drug, and should be given a lower initial dose of loratadine. In adults and children 6 years of age and older with renal impairment (a glomerular filtration rate less than 30 mL/minute) or hepatic failure should be initiated at a dosage of 10 mg every other day.