Lorinose Overdosage

Overdose and Treatment: In adults, drowsiness, tachycardia, and headache have been reported after overdoses (e.g., 40-180 mg) of loratadine tablets. In children, extrapyramidal manifestations and palpitations have been reported with overdoses (exceeding 10 mg) of loratadine syrup.
Treatment of loratadine overdosage generally involves symptomatic and supportive care, initiated promptly and maintained as long as necessary. In acute loratadine overdosage, the stomach should be emptied immediately by inducing emesis with ipecac syrup. Administration of activated charcoal after emesis may be useful in preventing absorption of loratadine. If induction of vomiting is unsuccessful or contraindicated (e.g., the patient is comatose, having seizure, or lacks the gag reflex), gastric lavage with a 0.9% sodium chloride solution may be performed if an endotracheal tube with cuff inflated is in place to prevent aspiration of gastric contents. Saline cathartics may be value to rapidly dilute bowel contents. Loratadine is not removed by hemodialysis. It is not known if loratadine is removed by peritoneal dialysis.