Lorinose Drug Interactions

Metabolism/Transport Effects: Substrate of CYP2D6 (minor), CYP3A4 (minor), P-glycoprotein/ABCB1.
Avoid Concomitant Use: Avoid concomitant use of Loratadine with any of the following: Aclidinium; Azelastine (Nasal); Bromperidol; Cimetropium; Eluxadoline; Glycopyrrolate (Oral Inhalation); Glycopyrronium (Topical); Ipratropium (Oral Inhalation); Lasmiditan; Levosulpiride; Orphenadrine; Oxatomide; Oxomemazine; Paraldehyde; Pitolisant; Potassium chloride; Potassium citrate; Revefenacin; Thalidomide; Tiotropium; Umeclidinium.
Increased Effect/Toxicity: Loratadine may increase the levels/effects of: Alcohol (Ethyl); Amezinium; Anticholinergic Agents; Azelastine (Nasal); Blonanserin; Brexanolone; Buprenorphine; Cimetropium; CNS Depressants; Eluxadoline; Flunitrazepam; Glucagon; Glycopyrrolate (Oral Inhalation); Hydrocodone; Methotrimeprazine; Metyrosine; Mirabegron; Opioid Agonists; Orphenadrine; Oxycodone; Paraldehyde; Piribedil; Potassium Chloride; Potassium citrate; Pramipexole; Ramosetron; Revefenacin; Ropinirole; Rotigotine; Selective Serotonin Reuptake Inhibitors; Suvorexant; Thalidomide; Thiazide and Thiazide-Like Diuretics; Tiotropium; Topiramate; Zolpidem.
The levels/effects of Loratadine may be increased by: Aclidinium; Alizapride; Amantadine; Amiodarone; Botulinum Toxin-Containing Products; Brimonidine (Topical); Bromopride; Bromperidol; Cannabidiol; Cannabis; Chloral Betaine; Chlormethiazole; Chlorphenesin Carbamate; Dimethindene (Topical); Doxylamine; Dronabinol; Droperidol; Erdafitinib; Esketamine; Glycopyrronium (Topical); Hydroxyzine; Ipratopium (Oral Inhalation); Kava Kava; Lasmiditan; Lemborexant; Lofexidine; Lumacaftor; Magnesium sulfate; Methotrimeprazine; Mianserin; Minocycline (Systemic); Nabilone; Oxatomide; Oxomemazine; Perampanel; P-glycoprotein/ABCB1 Inhibitors; Pramlintide; Ranolazine; Rufinamide; Sodium oxybate; Tapentadol; Tetrahydrocannabinol; Tetrahydrocannabinol and Cannabidiol; Trimeprazine; Umeclidinium.
Decreased Effect: Loratadine may decrease the levels/effects of: Acetylcholinesterase Inhibitors; Benzylpenicilloyl Polylysine; Betahistine; Gastrointestinal Agents (Prokinetic); Hyaluronidase; Itopride; Levosulpiride; Nitroglycerin; Pitolisant; Secretin.
The levels/effects of Loratadine may be decreased by: Acetylcholinesterase Inhibitors; Amphetamines; Lumacaftor; P-glycoprotein/ABCB1 Inducers.