Covir 800

Aciclovir

HSV infections of skin & mucous membranes including initial & recurrent genital herpes. Varicella infections (chickenpox) & herpes zoster (shingles). Suppression of recurrent herpes simplex infections in immune-competent patients. Prophylaxis of herpes simplex infections in immune-compromised patients. Management of severely immunocompromised patients w/ advanced HIV disease (CD4+ counts <200/mm³, including patients w/ AIDS or severe ARC) or following bone marrow transplantation.

Adult Treatment of herpes simplex 200 mg 5 times daily at approx 4-hr interval for 5 days. May double dose to 400 mg, or alternatively consider IV dosing in severely immune-compromised patients or w/ impaired gut absorption. Suppression of herpes simplex 400 mg bid at approx 12-hr interval. May titrate dose to 200 mg tid at approx 8-hr interval or bid at approx 12-hr interval. Immune-competent patients 200 mg qid at approx 6-hr interval. Prophylaxis of herpes simplex 200 mg qid at approx 6-hr interval. May double dose to 400 mg, or alternatively consider IV dosing in severely immune-compromised patients or w/ impaired gut absorption. Treatment of varicella & herpes zoster 800 mg 5 times daily at approx 4-hr interval for 7 days. Management of severely immunocompromised patients 800 mg qid at approx 6-hr interval. Treatment duration: 6 mth (1-7 mth post-transplant) in bone marrow transplant patients, 12 mth in patients w/ advanced HIV. Infant & childn 20 mg/kg qid for 5 days. Treatment of herpes simplex, prophylaxis of herpes simplex in immune-compromised Childn ≥2 yr Adult dose, <2 yr ½ of adult dose. Treatment of varicella infection Childn ≥6 yr 800 mg qid, 2 to <6 yr 400 mg qid, <2 yr 200 mg qid. Severe renal impairment (CrCl <10 mL/min) Treatment & prophylaxis of herpes simplex infections 200 mg bid at approx 12-hr interval. Treatment of varicella & herpes zoster infections, management of severely immunocompromised patients 800 mg bid at approx 12-hr interval. Moderate renal impairment (CrCl 10-25 mL/min) Treatment of varicella & herpes zoster infections, management of severely immunocompromised patients 800 mg tid at approx 8-hr interval.

May be taken with or without food: Swallow whole, do not split.

Hypersensitivity to aciclovir or valaciclovir.

Not for genital herpes. Avoid sexual contact in patients w/ STD while visible lesions are present. TTP/hemolytic uremic syndrome. Patients w/ encephalitis. Ensure adequate hydration. Concomitant use w/ other nephrotoxic drugs. Renal failure or patients undergoing hemodialysis. Pregnancy & lactation. Childn <2 yr. Elderly (monitor renal function).

Aggressive behavior, agitation, ataxia, coma, confusion, decreased consciousness, delirium, dizziness, dysarthria, encephalopathy, hallucinations, obtundation, paresthesia, psychosis, seizures, somnolence, tremors; alopecia, erythema multiforme, photosensitivity & pruritus rash, SJS, TEN, urticaria; diarrhea, GI distress, nausea; renal failure, elevated BUN & creatinine, hematuria; anemia, leukocytoclastic vasculitis, leukopenia, lymphadenopathy, thrombocytopenia; elevated LFTs, hepatitis, hyperbilirubinemia, jaundice; myalgia; visual abnormalities; anaphylaxis, fever, angioedema, headache, pain, peripheral edema.

Increased mean plasma t_½ & AUC, decreased urinary excretion & renal clearance w/ probenecid. May enhance nephrotoxic effect w/ foscarnet. May diminish therapeutic effect of varicella virus vaccine. May enhance CNS depressant effect of zidovudine.

Antivirals

J05AB01 - aciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.

D