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Concomitant administration of probenecid and aciclovir has reportedly increased the mean plasma half-life and area under the plasma concentration-time curve (AUC) and decreased urinary excretion and renal clearance of acyclovir.
Concomitant use of aciclovir and foscarnet may enhance the nephrotoxic effect of aciclovir.
Concomitant administration of aciclovir and varicella virus vaccine may diminish the therapeutic effect of varicella virus vaccine.
Concomitant use of aciclovir and zidovudine may enhance the CNS depressant effect of zidovudine.
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