Covir 800 Special Precautions

Patients receiving acyclovir for the treatment of genital herpes should be advised that aciclovir is not a cure for genital herpes because genital herpes is a sexually transmitted disease, they should avoid sexual contact while visible lesions are present since there is a risk of infecting their sexual partner.
Patients should be instructed to consult their clinician if severe or troublesome adverse effects occur during aciclovir therapy.
The recommended dosage and duration of aciclovir therapy should not be exceeded. The dose and dosage interval should be carefully adjusted in patients with renal failure or in patients undergoing hemodialysis to prevent drug accumulation, decrease the risk of toxicity, and maintain adequate plasma concentrations of aciclovir. Dosage adjustment should be based on estimated creatinine clearance.
Patients receiving other nephrotoxic drugs concurrently should be used aciclovir with caution since the risk of aciclovir-induced renal impairment and/or reversible CNS symptoms is increased. Adequate hydration should be maintained, however in patients with encephalitis, the recommended hydration should be balanced by the risk of cerebral edema.
Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome, which has resulted in death, has occurred in immunocompromised patients receiving acyclovir therapy.
Use in Pregnancy & Lactation: Female patients should be instructed to consult their physician if they become pregnant or intend to become pregnant or if they intend to breast-feed.
Use in Children: The safety and efficacy in children younger than 2 years of age have not been established.
Use in the Elderly: The duration of pain after healing was longer in those 65 years of age and older and nausea, vomiting, and dizziness were reported more frequently in geriatric patients. Geriatric patients are more likely than younger adults to have adverse CNS effects (e.g., coma, confusion, hallucinations, somnolence) during therapy. Geriatric patients also are more likely to have adverse renal effects during therapy and to have reduced renal function requiring dosage adjustment. Aciclovir dosage should be carefully selected for this age group and it may be useful to monitor renal function.