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Overdose and Treatment: Aciclovir overdosage involves ingesting up to 20 g of the drug. Overdosage of IV acyclovir has been reported following administration of rapid IV injections or inappropriately high doses and in patients with fluid and electrolyte imbalance, resulting in elevations in BUN and serum creatinine concentration and subsequent renal failure. Other adverse effects reported with aciclovir overdosage include agitation, coma, lethargy, and seizures. At renal concentrations exceeding 2.5 mg/mL, aciclovir crystals may precipitate in the renal tubules, possibly causing renal dysfunction and eventual renal failure and anuria.
If acute renal failure and anuria occur, use of hemodialysis should be considered until renal function is restored.
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