Zalvos Drug Interactions

As with other quinolones concurrent administration of Ciprofloxacin with Theophylline may lead to elevated serum concentrations of Theophylline and prolongation of its elimination half-life. This may result in increased risk Theophylline­-related adverse reactions. If concomitant use of Ciprofloxacin and Theophylline cannot be avoided, serum levels of Theophylline should be monitored and dosage adjustments made as appropriate.
Probenecid interferes with renal tubular secretion of Ciprofloxacin and produces an increase in the level of Ciprofloxacin in the serum.
This should be considered if patients are receiving both drugs concomitantly. As with other broad-spectrum antimicrobial agents, prolonged use of Ciprofloxacin may result in overgrowth of nonsusceptible organisms. Repeated evaluation of the patient's condition and microbial susceptibility testing are essential. If superinfection occurs during therapy, appropriate measures should be taken.