Zalvos Dosage/Direction for Use

Ciprofloxacin is given by intravenous infusion over 30 to 60 minutes as a solution of the lactate in a concentration of 1 to 2 mg per mL. The usual adult intravenous dose is 100 to 400 mg twice daily. For acute exacerbations of cystic fibrosis associated with Pseudomonas aeruginosa infection, ciprofloxacin may be given to adolescents and children ages 5 years or more in a dose of 10 mg per kg may be given intravenous infusion over 60 minutes three times daily, to a maximum of 400 mg three times daily. Or as prescribed by a physician.
Ciprofloxacin is not generally recommended for other uses in children and adolescents but if considered essential, doses of 4 to 8 mg per kg twice daily intravenously have been suggested. Doses should be reduced in patients with severe renal impairment. Halving the dose has been suggested when the creatinine clearance is less than 20 mL per minute or alternatively the dosage interval may be increased; ideally plasma concentrations of ciprofloxacin should be monitored.
Compatibility with common injection liquids: Ciprofloxacin is compatible with natural NaCl solution, Ringer solution, 5% Dextrose solution and 10% Dextrose solution and 10% Dextrose/NaCl solution and 10% Fructose.
Duration of treatment: The duration of treatment depends upon the severity of infection. For acute infections, the usual duration is 5-7 days. Generally, the administration should be continued for at least 3 days, after the signs and symptoms of infection have disappeared.
Parental therapy may be changed to oral Ciprofloxacin tablets.