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Antacids and other cations: Early investigational trials with quinolones revealed decreased ciprofloxacin absorption when co-administered with magnesium-aluminum antacids.
Theophylline: Theophylline serum concentrations have been found to be markedly elevated when co-administered with ciprofloxacin.
Other: Rifampicin may induce the metabolism of ciprofloxacin leading to lower serum concentrations and failure of therapy. The combination of ciprofloxacin and chloramphenicol may be antagonistic.
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