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There is limited experience on ciprofloxacin overdose and in events of acute overdosage, reversible renal toxicity has been reported. The patient should be carefully observed and given supportive treatment. The symptoms include dizziness, tremor, headache, tiredness, seizures, hallucinations, and confusion. It also include gastrointestinal upset liver, and kidney abnormalities, crystalluria and hematuria as well.
Treatment includes gastric lavage or induced vomiting. Activated charcoal, Magnesium of Calcium containing antacids can be administered to reduce the absorption of ciprofloxacin. Adequate hydration must be maintained as well. Only a small amount of ciprofloxacin (<10%) is eliminated through hemodialysis or peritoneal dialysis.
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