Ciprophil Drug Interactions

Ciprofloxacin may interfere with the clearance of the drugs metabolized by the liver such as theophylline and caffeine on account of the ability of ciprofloxacin to inhibit hepatic metabolism. In one study, seizures had developed after concomitant use of ciprofloxacin with theophylline.
Ciprofloxacin is not recommended to be administered orally within 4 hours of taking magnesium, aluminum or iron and zinc salts-containing antacids to prevent the reduction of absorption of ciprofloxacin as well as other fluoroquinolones. Sucralfate, which releases aluminum ions in the stomach, may reduce absorption of ciprofloxacin and other quinolones.
The possibility of interfering with the absorption of fluoroquinolones may be present in dairy products having high calcium content.
Although histamine H₂ antagonists affect the pharmacokinetics of ciprofloxacin, clinical effect is found insignificant.
Naproxen and chloroquine were found to cause adverse neurological effect with the addition of ciprofloxacin. Effect was reduced when the antirheumatic drugs were discontinued.
In surgical infection prophylaxis, concomitant administration of ciprofloxacin with opioid analgesics is not recommended as the peak serum concentrations of ciprofloxacin is reduced significantly.
Cytotoxic chemotherapy was reported to reduce the absorption of ciprofloxacin. Enhanced nephrotoxicity was developed after concomitant use of the ciprofloxacin with cyclosporine.
Plasma concentration of midazolam increases when administered with ciprofloxacin.
Probenecid was found to reduce the urinary excretion of ciprofloxacin without increasing plasma concentration of the latter.
Interference with Laboratory Results: In elderly patients treated with ciprofloxacin for urinary tract infections, a false positive reaction for urinary glucose (pseudoglycosuria) has been reported.