Alendra Drug Interactions

Calcium Supplements, Antacids and Other Multivalent Cations: Aluminum-, calcium-, iron-, or magnesium-containing compounds such as antacids, mineral supplements, and some osmotic laxatives may interfere with the absorption of alendronate and should therefore be given at least 30 minutes after taking alendronate.
Intravenous Ranitidine: Concomitant administration of intravenous ranitidine doubled the bioavailability of oral alendronate. However, it is not known whether the increased bioavailability has any clinical significance and if this increase in bioavailability will occur in patients who are receiving oral H2-antagonists.
Hormone Replacement Therapy (HRT): The degree of suppression of bone turnover as assessed by mineralizing surface is significantly greater when Hormone Replacement Therapy (HRT) such as estrogen ± progestin is combined with alendronate therapy than with either agent alone in studies of 1 to 2 years duration in postmenopausal women with osteoporosis.
Aspirin: Aspirin should be given with caution in patients receiving alendronate since these drugs may increase the incidence of gastrointestinal or renal adverse events.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Although NSAIDs may be given in patients receiving alendronate, NSAIDs should be given with caution since they may increase the incidence of gastrointestinal adverse events (i.e., gastrointestinal irritation).
Food and Beverages: Food and beverage other than plain water may markedly reduce the absorption and efficacy of alendronate. (See Dosage and Administration.)
Herbal: Take alendronate at least 30 minutes before taking any herbal product since herbal products may interfere with the absorption of alendronate when used concomitantly.
Oral Prednisone: Oral prednisone did not produce a clinically significant change in the oral bioavailability of alendronate (a mean increase ranging from 20-44%) in healthy subjects.