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Hypersensitivity to bisphosphonates or to any component of this product.
Abnormalities of the esophagus which delay esophageal emptying such as stricture or achalasia.
Inability to stand or sit upright for at least 30 minutes (e.g., bedridden and hospitalized patients).
Renal impairment with creatinine clearance < 35 mL/min.
Hypocalcemia (see General Precautions under Precautions).
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