HuMog Overdosage

The acute toxicity of menotrophin has been shown to be very low. However, too high a dosage for more than one day may lead to hyperstimulation, which is categorised as mild, moderate or severe. Symptoms of overdosage usually appear 3-6 days after treatment with human chorionic gonadotrophin.
Mild hyperstimulation: Symptoms include some abdominal swelling and pain; ovaries enlarged to about 5 cm diameter. Therapy: rest; careful observation and symptomatic relief. Ovarian enlargement declines rapidly.
Moderate hyperstimulation: Symptoms include more pronounced abdominal distension and pain; nausea; vomiting; occasional diarrhoea; ovaries enlarged up to 12 cm diameter. Therapy: bed rest; close observation especially in the case of conception occurring, to detect any progression to severe hyperstimulation. Pelvic examination of enlarged ovaries should be gentle in order to avoid rupture of the cysts. Symptoms subside spontaneously over 2-3 weeks.
Severe hyperstimulation: This is a rare but serious complication, symptoms include pronounced abdominal distension and pain; ascites; pleural effusion; decreased blood volume; reduced urine output; electrolyte imbalance and sometimes shock; ovaries enlarge to in excess of 12 cm diameter. Therapy: hospitalisation; treatment should be conservative and concentrate on restoring blood volume and preventing shock. Acute symptoms subside over several days and ovaries return to normal over 20-40 days if conception does not occur, symptoms may be prolonged if conception occurs.