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In females: Pregnancy; Enlargement of the ovaries or cysts that is not caused by polycystic ovarian syndrome; Gynaecological bleeding of unknown cause; Tumours in the uterus, ovaries and breasts.
In males: Carcinoma of the prostate; Tumours in the testes.
The following conditions should be properly treated before HMG-therapy is begun: dysfunction of the thyroid gland and of the cortex of the suprarenal gland, a rise in the serum level of prolactin with different causes (hyperprolactinaemia), tumours in the pituitary gland (hypophysis) or in part of the diencephalons (hypothalamus).
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