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ATC Code: G03GA02-Human Menopausal Gonadotropin.
Pharmacology: Pharmacodynamics: HuMoG (Human Menopausal Gonadotropin) is a hormonal substance containing FSH and LH in ration of 1:1.
In females, HuMoG stimulates both the growth and maturation of follicles. It induces an increase in the oestrogen levels and proliferation of the endometrium.
In males, HuMoG stimulates the spermatogenesis by acting on the production of the androgen-binding protein in the seminiferous tubules of the sertoli cells.
Pharmacokinetics: Human menopausal gonadotrophins (HMG) is not effective when taken orally and is injected intra-muscularly. The HMG biological effectiveness is mainly due to its FSH content. The pharmacokinetics of HMG following IM administration shows great individual variations. The maximum serum level of FSH is reached 6-24 hours after injection, resp. 6-36 hours after SC injection. After that the serum level decreases by a half-life of 56 (IM) resp.51 (SC) hours.
Administered HMG is predominantly discharged renally.
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