HuMog Dosage/Direction for Use

Unless prescribed otherwise, dose as follows: Sterility in females: The dosage of HMG for the induction of follicle growth in normo- or hypogonadotrophic women varies according to the individual. The amount depends on ovarian reaction and should be checked by ultrasound examinations of the ovaries and measuring estradiol levels. If the HMG dosage is too high for the treated individual, multiple uni- and bilateral follicle growth can occur.
HMG is administered intramuscularly or subcutaneously and in general, the therapy is begun with a daily dosage corresponding to 75-150 IU FSH. If the ovaries do not respond, the dosage can slowly be increased until a rise in estradiol secretion and follicle growth is evident. Treatment with the same dosage of HMG continues until the preovulatory estradiol serum level is attained. If the level rises too quickly, the dosage should be reduced. To induce ovulation, 5,000 or 10,000 IU HCG are injected IM 1 to 2 days after the last HMG administration.
Note: After administering a HMG dosage which is too high for the corresponding individual, a subsequent HCG administration can cause an unintentional hyperstimulation of the ovaries.
Sterility in males: Initially, 3 x 1,000 and 3,000 IU HCG a week are administered until a normal testosterone serum level is reached. Then, an additional dose of HMG (3 x 75-150 IU FSH + 75-150 IU LH) per week is administered IM for a few months. Treatment should be continued for at least 3 or 4 months.
Reconstitution Instructions: Reconstitute powder of vial in 1ml of Sodium Chloride Injection BP provided in the pack immediately prior to use. Up to 5 vials of HuMoG may be reconstituted in 1ml of Sodium Chloride Injection BP.
Route of Administration: Intramuscular (IM) + Subcutaneous (SC).