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Problems of overdosage with amoxicillin are unlikely to occur. If encountered, gastrointestinal effects eg, nausea, vomiting and diarrhea may be evident and should be treated symptomatically with attention to the water/electrolyte balance.
During the administration of high doses of amoxicillin, adequate fluid intake and urinary output must be maintained to minimize the possibility of amoxicillin crystalluria.
Amoxicillin can be removed from the circulation by hemodialysis.
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