Amoxil/Amoxil Forte Dosage/Direction for Use

Usual Dosage: Treatment of Infection: Adults and Children >40 kg: For Severe Infections: 875 mg every 12 hrs or 500 mg 3 times daily.
Gonorrhea: Single 3-g dose.
Children <40 kg: Standard Dosage: 125 mg 3 times daily, increasing to 250 mg 3 times daily for more severe infections.
Amoxil Pediatric suspension is recommended for children <6 months.
In severe or recurrent acute otitis media, especially where compliance may be a problem, 750 mg twice a day for 2 days may be used as an alternative course of treatment in children 3-10 years.
Renal Impairment: In renal impairment, the excretion of the antibiotic will be delayed and, depending on the degree of impairment, it may be necessary to reduce the total daily dosage according to the following scheme:
Adults and Children >40 kg: Mild Impairment (Creatinine clearance >30 mL/min): No change in dosage. Moderate Impairment (Creatinine clearance 10-30 mL/min): Maximum of 500 mg twice daily. Severe Impairment (Creatinine clearance <10 mL/min): Maximum of 500 mg/day.
Patients Receiving Hemodialysis: Dosing as for patients with severe renal impairment (Creatinine clearance <10 mL/min). They should receive an additional dose both during and at the end of dialysis.
Amoxicillin is removed from the circulation by hemodialysis. Therefore, 1 additional dose (500 mg for adults or 15 mg/kg for children <40 kg) may be administered during dialysis and at the end of each dialysis.
It should be recognized that in the treatment of chronic urinary tract infections, frequent bacteriological and clinical appraisals are necessary.
Smaller doses than those recommended previously should not be used.
Even higher doses may be needed at times. In stubborn infections, therapy may be required for several weeks. It may be necessary to continue clinical and/or bacteriological follow-up for several months after cessation of therapy.
Except for gonorrhea, treatment should be continued for a minimum of 48-72 hrs beyond the time that the patient becomes symptomatic or evidence of bacterial eradication has been obtained. It is recommended that there be at least 10 days of treatment for any infection caused by Streptococcus pyogenes to prevent the occurrence of acute rheumatic fever.
Parenteral therapy is indicated if the oral route is considered impracticable or unsuitable, and particularly for the urgent treatment of severe infection.