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Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use with Amoxil may result in increased and prolonged blood levels of amoxicillin.
In common with other broad-spectrum antibiotics, Amoxil may reduce the efficacy of oral contraceptives and patients should be warned accordingly.
Concurrent administration of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions.
Prolongation of prothrombin time has been reported rarely in patients receiving amoxicillin.
Appropriate monitoring should be undertaken when anticoagulants are prescribed concurrently.
It is recommended that when testing for the presence of glucose in urine during amoxicillin treatment, enzymatic glucose oxidase methods should be used. Due to the high urinary concentrations of amoxicillin, false-positive reading are common with chemical methods.
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