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Caution should be exercised when used in the elderly, patients with bronchospasm, bleeding disorders, cardiovascular disease, and in liver or renal failure.
Patients with congestive heart failure, cirrhosis, diuretic-induced volume depletion, or renal insufficiency require local synthesis of vasodilating prostaglandins to maintain renal perfusion, and therefore, these patients are at greater risk of developing renal dysfunction due to NSAID-induced inhibition of renal prostaglandin synthesis.
Patients who develop diarrhoea or rash while receiving mefenamic acid should discontinue therapy.
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