Pongesic Drug Interactions

Notable interactions involving NSAIDs include possible enhancement of the effects of oral anticoagulants and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with angiotensin-converting enzyme inhibitors, cyclosporin, or diuretics. There may also be an increased risk of hyperkalaemia with angiotensin-converting enzyme inhibitors and potassium-sparing diuretics. The antihypertensive effects of some antihypertensive agents including angiotensin-converting enzyme inhibitors, beta blockers, and diuretics may be reduced. Convulsions may occur due to an interaction with quinolones. NSAIDs may enhance the effects of phenytoin and sulphonylurea anti-diabetics. The concomitant use of more than one NSAID should be avoided because of the increased risk of adverse effects. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids. Some NSAIDs can interfere with thyroid function tests by lowering serum thyroid hormone concentrations.