Contraindications to coordination: Levodopa: there is a competitive antagonism between levodopa and neuroleptics. In the case of extrapyramidal syndrome caused by neuroleptics, levodopa (because dopaminergic receptors have been blocked by neuroleptics) should not be used, but anticholinergic drugs should be used.
In patients with palsy (parkinson) treated with levodopa, in cases where neuroleptic treatment is required, levodopa should not be continued because it may aggravate psychiatric disorders and may have an effect on receptors that have been blocked by neuroleptics.
Caution when coordinating: Alcohol: alcohol can increase the sedative effect of sedatives.
Avoid alcohol and alcohol-containing drugs or drinks.
Notes when coordinating: Hypertension drugs: increase the effect of lowering blood pressure and can cause postural hypotension (due to synergistic effects).
Other central nervous system depressants: antidepressants with sedative effects, H1 antihistamines with sedative effects, barbiturates, anxiolytic sedatives, clonidine and similar drugs, sleeping pills, methadone: increase central nervous system inhibition, can have bad consequences, especially in people who have to drive or operate machines.