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Adverse reactions associated with sulpiride are: Cardiac disorders: Postural hypotension.
QT interval prolongation and ventricular arrhythmias, such as torsade de pointes, ventricular tachycardia, which can cause ventricular fibrillation or cardiac arrest, sudden death (see Warnings).
Endocrine disorders: Hyperprolactinaemia.
General disorders and administration site conditions: Like all neuroleptics, malignant syndrome is a potentially life-threatening complication (see Warnings).
Weight gain.
Hepatobiliary disorders: Increase in liver enzymes.
Nervous system disorders: Sedation or drowsiness.
Extrapyramidal symptoms and related disorders: parkinsonism and associated symptoms: tremor, hypertonia, hypokinesia, hypersalivation; acute dyskinesia and dystonia (spasmodic torticollis, oculogyric crises, trismus); akathisia.
These symptoms are generally reversible if anti-Parkinson's medication is administered: Tardive dyskinesia (characterised by involuntary and rhythmic movements mainly of the tongue and/or face), typical of all neuroleptics, after administration for more than 3 months. The anti-Parkinson's medication is ineffective or may exacerbate symptoms.
Seizures (see Precautions).
Reproductive system and breast disorders: Disorders related to hyperprolactinaemia: Galactorrhoea, amenorrhoea, gynaecomastia, increased chest, chest pain, orgasmic dysfunction, erectile dysfunction.
Skin and subcutaneous tissue disorders: Maculopapular rash.
Vascular disorders: Venous thromboembolism, including pulmonary embolism, sometimes fatal, and deep vein thrombosis (see Warnings).
Pregnancy, puerperium and perinatal conditions: Unknown frequency: Neonatal withdrawal syndrome (see Use in Pregnancy & Lactation).
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