Pregnancy: Colchicine has been shown to cause teratogens in animals and poses a risk of teratogenicity or fetal chromosomal damage in humans. Colchicine should not be used in the first trimester of pregnancy and only in the late stages of pregnancy when considering the risks/benefits because colchicine can be excreted through breast milk.
Lactation: It should not be used by women who are breastfeeding because of the risk of cytotoxicity.