Đăng xuất
Peripheral neuropathy, myopathy, rhabdomyolysis, alopecia, azoospermia and, with prolonged treatment, bone marrow impairment with the presence of agranulocytosis, thrombocytopoenia and aplastic anaemia, have been reported occasionally.
Treatment should be discontinued upon presentation of the first symptom of nausea, vomiting and abdominal pain or diarrhoea, and the patient should attend an emergency room.
According to the AGREE study (see Pharmacology: Pharmacodynamics under Actions), in which 185 patients with acute gout attack were distributed into three different treatment groups, namely treatment with high doses of colchicine [1.2 mg followed by 0.6 mg every hour for 6 hours; (total: 4.8 mg)], treatment with low doses [1.2 mg followed by 0.6 mg in the following hour; (total: 1.8 mg)] and treatment with placebo, the incidence of adverse reactions in the different groups was 76.9%, 36.5% and 27.1% respectively. The incidence of adverse reactions reported most commonly is given as follows. (See table.)
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