Đăng xuất
Bone marrow suppression, with aplastic anemia, agranulocytosis, leukopenia, or thrombocytopenia, may occur in patients receiving long-term treatment. Loss of hair, rashes, bullous dermatitis, peripheral neuritis or neuropathy, myopathy, anuria, kidney damage, hematuria, and purpura have been reported with prolonged administration of colchicine.
Vomiting, diarrhea, abdominal pain, and nausea may occur especially when maximum doses are required for therapeutic effect. These symptoms are particularly concerning for patients with peptic ulcer disease or colonic spasm.
At toxic doses, colchicine can cause severe diarrhea, systemic vascular damage, and kidney injury with hematuria and oliguria. To prevent severe toxicity, discontinue colchicine immediately if these symptoms appear, regardless of joint pain relief.
Skin lesions have been reported, and hypersensitivity reactions may occur, though they are uncommon.
Hepatobiliary disorders: Liver toxicity has been observed, but the exact frequency is unknown.
Report any adverse effects to a doctor or pharmacist immediately.
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