As dipyridamole is a known inhibitor of adenosine uptake, it may potentiate the action of Sanacore; in one study dipyridamole was shown to produce a 4-fold increase in adenosine actions. Asystole has been reported following concomitant administration. It is therefore suggested that Sanacore should not be administered to patients receiving dipyridamole; if use of Sanacore is essential, dipyramidole should be discontinued 24 hours beforehand or 4-fold of the dosage of Sanacore should be reduced. (e.g. initial dose: 0.5 to 1.0 mg).
Aminophylline, theophylline and other xanthines are competitive adenosine antagonists and should be avoided for 24 hours prior to use of adenosine.
Food and drinks containing xanthines (tea, coffee, chocolate and cola) should be avoided for at least 12 hours prior to use of adenosine.
Sanacore may interact with drugs tending to impair cardiac conduction.
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