Sanacore Adverse Reactions

Frequencies provided refer to legacy data. For newly included safety items, which are based exclusively on post-marketing experience, the frequency listed is; "Not known".
The following CIOMS frequency rating is used, where applicable: Very common: ≥10%; Common: ≥1% and <10%; Uncommon: ≥0.1% and <1%; Rare: ≥0.01% and <0.1%; Very rare: <0.01%.
These side effects are generally mild, of short duration (usually less than 1 minute) and well tolerated by the patient. However severe reactions can occur.
Cardiac disorders: Very common: Bradycardia, Atrioventricular block, Sinus pause, Atrial extrasystoles, Skipped beats, Ventricular excitability disorders such as ventricular extrasystoles, non-sustained ventricular tachycardia.
Uncommon: Sinus tachycardia, Palpitations.
Very rare: Severe bradycardia which is not corrected by atropine and may require temporary pacing, Atrial fibrillation, Ventricular excitability including ventricular fibrillation.
Not known: Asystole/Cardiac arrest, sometimes fatal especially in patients with underlying ischemic heart disease/cardiac disorder, MI/ST segment elevation especially in patients with pre-existing severe CAD.
Adenosine induced bradycardia predisposes to ventricular excitability disorders, including ventricular fibrillation and torsade de pointes, which justify the recommendations made in "Dosage & Administration". The previous text mentions cardiac arrhythmias occur at the time of conversion to normal sinus rhythm.
Nervous system disorders: Common: Headache, Dizziness/light-headedness.
Uncommon: Head pressure.
Very rare: Transient and spontaneously and rapidly reversible worsening of intracranial hypertension.
Not known: Loss of consciousness/syncope, Convulsions, especially in predisposed patients.
Eye disorders: Uncommon: Blurred vision.
Respiratory, thoracic and mediastinal disorders: Very common: Dyspnea (or the urge to take a deep breath).
Uncommon: Hyperventilation.
Very rare: Bronchospasm.
Not known: Respiratory failure, Apnea/Respiratory arrest.
Cases with fatal outcome of respiratory failure, of bronchospasm, and of apnea/respiratory arrest have been reported.
Gastro-intestinal system disorders: Common: Nausea.
Uncommon: Metallic taste.
Not known: Vomiting.
Vascular disorders: Very common: Flushing.
Not known: Hypotension sometimes severe, Cerebrovascular accident/transient ischemic attack; secondary to the hemodynamic effects of adenosine including hypotension.
General disorders and Administration Site conditions: Very common: Chest pressure/pain, feeling of thoracic constriction/oppression.
Common: Burning sensation.
Uncommon: Heaviness in arms, Arm, neck and back pain, Feeling of general discomfort/weakness/pain.
Very rare: Injection site reactions.
Psychiatric disorders: Common: Apprehension.
Immune system disorders: Not known: Anaphylactic reaction (including angioedema and skin reactions such as urticarial and rash).