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Overdose and treatment: Overdose has been associated with vomiting, facial flushing, cheilosis, abdominal pain, headache, dizziness and ataxia. All symptoms quickly resolved without apparent residual effects.
An overdose would be expected to result in higher levels of isotretinoin in semen than found during a normal treatment course, men should use a condom, or avoid reproductive sexual activity with a female patient who is or might become pregnant, for 1 month after the overdose.
Isotretinoin cause serious birth defects at any dosage, so female patients of childbearing potential who present with isotretinoin overdose must be evaluated for pregnancy.
Patients who are pregnant should receive counselling about the risks to the fetus.
Non-pregnant patients must be warned and counseling about contraceptive to avoid pregnancy for at least 1 month after the overdose.
All patients with isotretinoin overdose should not donate blood for at least 1 month.
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